HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Phenylmethyl)pyridine → 2-(3-Fluoro-2-methyl-benzyl)-1-phenyl-indolizine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Phenylmethyl)pyridine | HCID 7581 | — |
| Reactant | 1-Bromo-3-(3-fluoro-2-methyl-phenyl)-propan-2-one | HCID 86670667 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | 2-(3-Fluoro-2-methyl-benzyl)-1-phenyl-indolizine | HCID 67773024 | 33.8% |
Reaction Steps
The compound of step 2 (1.50 g, 6.12 mmol) and 2-benzyl-pyridine (2.071 g, 12.24 mmol) were dissolved in acetone (30 ml) and the mixture was stirred under reflux overnight. The mixture was concentrated to dryness and the residue was purified by chromatography on silica gel (cyclohexane) to give 0.653 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415336B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-a857ff382b0a4e8abaa8d4ebf918fd2d |
| Source note | uspto-grants-2013_04 |