2-(Phenylmethyl)pyridine → HCID 67772676, compound

HRID 1963049Notes

Reaction equation

HRID 1963049 reaction equation
Br[CH2:2][C:3](=O)[CH2:4][C:5]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:12].[CH2:14]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CC(C)=O>[Cl:12][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]([F:11])[C:5]=1[CH2:4][C:3]1[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:21]2[N:22]([CH:2]=1)[CH:23]=[CH:24][CH:25]=[CH:26]2

Participants

4

Reactant 2

HCID 75812-(Phenylmethyl)pyridineHCID 80147526HCID 80147526, compound

Product 1

HCID 67772676HCID 67772676, compoundYield 76.3%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

The compound of step 1 (1.17 g, 4.41 mmol) and 2-benzyl-pyridine (1.49 g, 8.82 mmol) were dissolved in acetone (15 ml) and the mixture was stirred under reflux overnight. The mixture was concentrated to dryness and the residue was purified by chromatography on silica gel (DCM/MOH, 100:0, then 95:5) to give 1.13 g of the title compound.

Workup

  1. temperatureunder reflux overnight
  2. concentrationThe mixture was concentrated to dryness
  3. customthe residue was purified by chromatography on silica gel (DCM/MOH, 100:0

Sources & evidence

ORD record
ord-f019980b3a7a4707b5c4643159388c93
Source dataset
uspto-grants-2013_04
Patent number
US08415336B2

Reaction notes

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