1,1-Dimethylethyl 2-(2-methylpropyl)-4,6-dioxo-1-piperidinecarboxylate → 6-(2-methylpropyl)piperidine-2,4-dione

Participants

Reaction Steps

To a solution of tert-butyl 2-isobutyl-4,6-dioxopiperidine-1-carboxylate (30 g, 0.114 mol) in dry 1,4 dioxane (300 mL), HCl (3 M in 1,4 dioxane, 100 mL) was added and stirred at room temperature for 3 h. The reaction mixture was concentrated and purified by crystallization using diethyl ether to yield 6-isobutyl-piperidine-2,4-dione (14 g, 74%) as a white solid.

Provenance & Evidence