HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tosylmethyl isocyanide → HCID 66732195, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tosylmethyl isocyanide | HCID 161915 | — |
| Reactant | Potassium tert-butoxide | HCID 23665647 | — |
| Reactant | HCID 66731706 | HCID 66731706 | — |
| Product | HCID 66732195 | HCID 66732195 | — |
Reaction Steps
The compound was prepared as described in Reference Compound 1, Step 1 from 2-Isobutyl-4-oxo-piperidine-1-carboxylic acid tert-butyl ester (4.55 g, 17.8 mmol), toluene-4-sulfonylmethyl isocyanide (5.2 g, 26.7 mmol) and potassium tert-butoxide (53.4 mL, 1 M in tert-butanol) which yielded crude tert-butyl 4-cyano-2-isobutylpiperidine-1-carboxylate. MS m/z 267 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415378B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-d03cfe8402144a3ab910724722eb8d07 |
| Source note | uspto-grants-2013_04 |