HCID 66734647, compound → HCID 66732040, compound

Participants

Reaction Steps

Methyl 4-oxo-2-phenethyl-3,4-dihydropyridine-1(2H)-carboxylate (21.7 g, ca 75 mmol) was hydrogenated over Pd/C (5%) in EtOAc at 5 bar for 20 h. The mixture was filtered through a silica plug and then evaporated to give the product as an oil (19.8 g). 1H NMR (600 MHz, cdcl3) δ 1.69 (m, 1H), 1.80 (m, 1H), 2.26 (m, 2H), 2.41 (m, 1H), 2.47-2.70 (m, 3H), 3.16 (m, 1H), 3.69 (m, 3H), 4.15-4.48 (br m, 2H), 7.14-7.30 (m, 5H). MS 262 m/z (M+H)+.

Provenance & Evidence