Tetrabutylammonium Fluoride → 1-Piperidinecarboxylic acid, 2-(2,2-dimethylpropyl)-4-(hydroxymethyl)-, methyl ester

Participants

Reaction Steps

The compound was prepared as described in Reference Compound 4, Step 4 starting from methyl 4-((tert-butyldimethylsilyloxy)methyl)-2-neopentylpiperidine-1-carboxylate and TBAF (34.2 mL, 34.2 mmol, 1 M in THF). The residue was purified by automated flash column chromatography on a Biotage® KP-SIL 340 g column. A gradient from 30% to 100% EtOAc in heptane was used as eluent, which resulted in the title compound.

Provenance & Evidence