HCID 66732259, compound → HCID 66731779, compound

Participants

Reaction Steps

Methyl 2-(3-(trifluoromethyl)phenyl)isonicotinate (2.6 g, 9.25 mmol) was dissolved in acetic acid (40 mL) and platinum(IV) oxide (0.210 g, 0.92 mmol) added. The resulting mixture was hydrogenated in a Büchi hydrogenator at room temperature and 5 bar for 3 h. The catalyst was filtered off, washed with MeOH and the eluate evaporated. DCM and 1 M K2CO3 were added and the phases separated. The organic layer was washed with brine, passed through a phase separator and evaporated to yield methyl 2-(3-(trifluoromethyl)phenyl)piperidine-4-carboxylate (1.4 g, 52%) as a slightly brown oil. MS m/z 288 (M+H)+

Provenance & Evidence