HCID 66731691, compound → HCID 66732517, compound

Participants

Reaction Steps

Methyl 6′-(trifluoromethyl)-2,3′-bipyridine-4-carboxylate hydrochloride (2.5 g, 7.86 mmol) was dissolved in MeOH (20 mL) and platinum(IV) oxide (0.036 g, 0.16 mmol) added. The resulting mixture was hydrogenated in a Büchi hydrogenator at room temperature and 5 bar for 1 h. Additional catalyst was added and the hydrogenation was continued for 1 h. The catalyst was filtered off, washed with MeOH and the eluate evaporated yielding methyl 2-(6-(trifluoromethyl)pyridin-3-yl)piperidine-4-carboxylate hydrochloride (2.2 g, 86%) as a brown solid. MS m/z 289 (M+H)+

Provenance & Evidence