Methyl 2-(2,4-difluorophenyl)isonicotinate hydrochloride → Methyl 2-(2,4-difluorophenyl)piperidine-4-carboxylate hydrochloride

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Reaction Steps

Methyl 2-(2,4-difluorophenyl)isonicotinate hydrochloride (3.93 g, 13.76 mmol) was dissolved in MeOH (40 mL) and platinum(IV) oxide (0.312 g, 1.38 mmol) added. The resulting mixture was hydrogenated in a Büchi hydrogenator at room temperature and 5 bar for 2 h. The catalyst was filtered off, washed with MeOH and the eluate evaporated leaving methyl 2-(2,4-difluorophenyl)piperidine-4-carboxylate hydrochloride (2.34 g, 58%) as a slightly yellow solid. MS m/z 256 (M+H)+

Provenance & Evidence