HCID 66731948, compound → HCID 66732576, compound

Participants

Reaction Steps

Methyl 2-(4-chloro-2-fluorophenyl)isonicotinate hydrochloride (7.26 g, 24.03 mmol) was dissolved in MeOH (100 mL) and platinum(IV) oxide (0.546 g, 2.40 mmol) added. The resulting mixture was hydrogenated in a Büchi hydrogenator at room temperature and 5 bar for 1 h. The catalyst was filtered off and washed with MeOH and the eluate evaporated yielding methyl 2-(4-chloro-2-fluorophenyl)piperidine-4-carboxylate hydrochloride (7.45 g, quant.) as a brown solid. MS m/z 272 (M+H)+

Provenance & Evidence