HCID 66731664, compound → HCID 66731612, compound

Participants

Reaction Steps

Methyl 2-(2-chloro-4-fluorophenyl)isonicotinate hydrochloride (2.35 g, 7.78 mmol) was dissolved in methanol (50 mL) and platinum(IV) oxide (0.177 g, 0.78 mmol) was added. The reaction mixture was hydrogenated in a Büchi hydrogenator at 5 bar and room temperature for 9 h. The catalyst was removed by filtration and the solvent was evaporated. The residue was dissolved in methanol (50.0 mL) and platinum(IV) oxide (144 mg, 0.63 mmol) was added. Hydrogenation was continued at 5 bar and room temperature for 4 h. The catalyst was removed by filtration and the solvent was evaporated. Crude methyl 2-(2-chloro-4-fluorophenyl)piperidine-4-carboxylate hydrochloride (2.4 g, 100%) was obtained as a yellow solid. MS m/z 272 (M+H)+

Provenance & Evidence