HCID 68502433, compound → HCID 66731744, compound

Participants

Reaction Steps

Methyl 2-(2,4-dichlorophenyl)isonicotinate hydrochloride (2.60 g, 8.15 mmol) was dissolved in MeOH (50 mL), added platinum(IV) oxide (0.019 g, 0.08 mmol) and hydrogenated in a Büchi hydrogenator at 5 bar for 90 min. The reaction mixture was filtered and evaporated to give crude methyl 2-(2,4-dichlorophenyl)piperidine-4-carboxylate hydrochloride (2.8 g) as a white solid. MS m/z 288 (M+H)+

Provenance & Evidence