Triethylamine → HCID 66731635, compound

Participants

Reaction Steps

Dimethyl 2-(2,4-dichlorophenyl)piperidine-1,4-dicarboxylate (2.78 g, 8.03 mmol) was dissolved in acetonitrile (27.1 mL) and water (0.542 mL). Lithium bromide (5.58 g, 64.24 mmol) and triethylamine (4.48 mL, 32.12 mmol) were added and the resulting mixture heated under reflux for 4 h, diluted with Water and MTBE and the organic layer extracted with water. The combined aqueous layers were acidified with 3 M HCl, extracted with MTBE, dried over MgSO4, filtered and evaporated to give 2-(2,4-dichlorophenyl)-1-(methoxy-carbonyl)piperidine-4-carboxylic acid (2.440 g, 91%) as a foam. MS m/z 332 (M+H)+

Provenance & Evidence