Triethylamine → HCID 66731516, compound

Participants

Reaction Steps

Dimethyl 2-(3,5-dichlorophenyl)piperidine-1,4-dicarboxylate (5.3 g, 15.31 mmol) was dissolved in acetonitrile (51.7 mL). Water (1.033 mL), lithium bromide (10.64 g, 122.47 mmol) and triethylamine (8.53 mL, 61.24 mmol) were added and the resulting mixture was heated under reflux for 2.5 h. It was diluted with water and MTBE. The aqueous layer was extracted with water. The combined aqueous layers were acidified with 3 M HCl, extracted with MTBE, dried over MgSO4, filtered and evaporated to give 2-(3,5-dichlorophenyl)-1-(methoxycarbonyl)piperidine-4-carboxylic acid (4.60 g, 90%) as a greenish foam. MS m/z 330 (M−H)−

Provenance & Evidence