Hydrochloric Acid → Dimethyl 2-(2-fluoro-4-(trifluoromethoxy)phenyl)piperidine-1,4-dicarboxylate

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Reaction Steps

Methyl 2-(2-fluoro-4-(trifluoromethoxy)phenyl)piperidine-4-carboxylate hydrochloride (4.97 g, 13.89 mmol) was dissolved in dichloromethane (50 mL) and DIPEA (6.05 mL, 34.73 mmol). Methyl carbonochloridate (1.313 mL, 16.67 mmol) was added and the reaction mixture was stirred at room temperature for 4 h. 0.1 M HCl was added and the aqueous layer extracted with DCM. The combined organic layers were filtered through a phase separator and evaporated. Crude dimethyl 2-(2-fluoro-4-(trifluoromethoxy)phenyl)piperidine-1,4-dicarboxylate (5.39 g, 102%) was obtained as a yellow oil. MS m/z 380 (M+H)+

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