Hydrochloric Acid → HCID 68507235, Verbindung

HRID 1963197Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1963197
[F:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:11]=[C:12]([CH:17]=[CH:18][N:19]=2)[C:13]([O:15][CH3:16])=[O:14])[CH:5]=[C:6]([F:9])[C:7]=1[F:8].[ClH:20]>CC(OC)(C)C>[ClH:20].[F:9][C:6]1[CH:5]=[C:4]([C:10]2[CH:11]=[C:12]([CH:17]=[CH:18][N:19]=2)[C:13]([O:15][CH3:16])=[O:14])[CH:3]=[C:2]([F:1])[C:7]=1[F:8]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 66732308Methyl 2-(3,4,5-trifluorophenyl)isonicotinate

Produkt 1

HCID 68507235HCID 68507235, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 15413tert-Butyl methyl etherLösungsmittel

Versuchsvorschrift

Methyl 2-(3,4,5-trifluorophenyl)isonicotinate (2.62 g) was dissolved in MTBE, then HCl (4 M in dioxane, 15 mL) was added. The solvents were evaporated to give methyl 2-(3,4,5-trifluorophenyl)isonicotinate hydrochloride (2.94 g, 9.68 mmol), which was dissolved in MeOH (40 mL) and platinum(IV) oxide (0.220 g, 0.97 mmol) added. The resulting mixture was hydrogenated in a Büchi hydrogenator at room temperature and 5 bar for 1 h. The catalyst was filtered off, washed with MeOH and the eluate evaporated yielding methyl 2-(3,4,5-trifluorophenyl)piperidine-4-carboxylate hydrochloride (2.75 g, 92%) as a brown solid. MS m/z 274 (M+H)+

Aufarbeitung

  1. customThe solvents were evaporated

Quellen und Nachweise

ORD-Eintrag
ord-14dff0e9d2374917a56d54c8833eac1c
Quelldatensatz
uspto-grants-2013_04
Patentnummer
US08415378B2

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