HCID 66732376, compound → HCID 66731669, compound

Participants

Reaction Steps

Methyl 2-(4-chloro-3,5-difluorophenyl)isonicotinate hydrochloride (1.94 g, 6.06 mmol) was dissolved in methanol. Platinum(IV) oxide (0.138 g, 0.61 mmol) was added and the mixture was hydrogenated at 5 bar at room temperature in a Büchi hydrogenator for 7 h. The catalyst was removed by filtration and the solvent evaporated. Methyl 2-(4-chloro-3,5-difluoro-phenyl)piperidine-4-carboxylate hydrochloride (1.820 g, 92%) was yielded as a colorless oil. MS m/z 290 (M+H)+

Provenance & Evidence