HCID 66731903, compound → HCID 66732196, compound

Participants

Reaction Steps

Methyl 2-(3-methyl-4-(trifluoromethyl)phenyl)isonicotinate (2.32 g, 7.86 mmol) was dissolved in acetic acid (150 mL) and platinum(IV) oxide (36 mg, 0.16 mmol) was added. Hydrogenation in a Büchi hydrogenator at room temperature and 6 bar for 2 h. The catalyst was filtered off. More platinum(IV) oxide was added and hydrogenation continued until starting material was consumed. Catalyst was filtered off and the solvent was evaporated to yield crude methyl 2-(3-methyl-4-(trifluoromethyl)phenyl)piperidine-4-carboxylate (2.60 g, 110%).

Provenance & Evidence