Hydrochloric Acid → HCID 59536568, compound

Participants

Reaction Steps

Dimethyl 2-(difluoromethyl)piperidine-1,4-dicarboxylate (2.35 g, 9.35 mmol) was dissolved in THF (35 mL) and 1 M lithium hydroxide (12.16 mL, 12.16 mmol) in water was added. The mixture was stirred at room temperature for 3 h, then 1 M HCl and DCM were added and the phases were separated. The aqueous phase was extracted with DCM and the combined organic layers were dried by filtration through a phase separator and evaporated. 2-(Difluoromethyl)-1-(methoxycarbonyl)piperidine-4-carboxylic acid (2.2 g, 99%) was isolated. MS m/z 275 (M−H)−

Provenance & Evidence