Iodine → HCID 178506003, compound

Participants

Reaction Conditions

Reaction Steps

Zinc powder (1.43 g, 21.87 mmol) was added to a dried flask and was heated at 70° C. under vacuum for 30 minutes. Dry DMA (29 mL) and iodine (0.092 g, 0.37 mmol) were added and the mixture was heated at 70° C. until the red-brown colour had disappeared (approx. 5 minutes). 4-(Bromomethyl)-1,1-difluorocyclohexane (3.1 g, 14.55 mmol) was added and heating was continued for ca. 42 h. The resulting solution was used in the next transformation.

Provenance & Evidence