HuagongsheHuagongshe Chemistry Print Report · For research reference only
(E)-Methyl 2-(4-fluorostyryl)isonicotinate → Methyl 2-(4-fluorophenethyl)isonicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (E)-Methyl 2-(4-fluorostyryl)isonicotinate | HCID 66732050 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 2-(4-fluorophenethyl)isonicotinate | HCID 66731796 | 100.1% |
Reaction Steps
(E)-methyl 2-(4-fluorostyryl)isonicotinate (3.6 g, 13.99 mmol) was dissolved in methanol (200 mL). Palladium on charcoal (0.149 g, 1.40 mmol) was added and the mixture was hydrogenated at atmospheric pressure and room temperature for 18 h. The catalyst was filtered off and the filtrate was evaporated. Methyl 2-(4-fluorophenethyl)isonicotinate (3.63 g, 99%) was isolated. MS m/z 260 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415378B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-c5aca35cd6ee4c5bb7f054ea2429835a |
| Source note | uspto-grants-2013_04 |