Hydrochloric Acid → HCID 66731842, compound

Participants

Reaction Steps

To crude 2-(4-chlorobenzyl)piperidine-4-carboxylic acid hydrochloride (5.34 g, 20.9 mmol) was added HCl (1.25 M in MeOH, 60 mL). The resulting suspension was refluxed for 2 h and then concentrated to give a slightly yellow solid. The residue was taken up in satd NaHCO3 (100 mL). The aqueous phase was extracted with DCM (×3), the combined organic layers dried with a phase separator and evaporated to yield methyl 2-(4-chlorobenzyl)piperidine-4-carboxylate (3.85 g, 87%) as a brown oil. MS m/z 268, 270 (M+H)+

Provenance & Evidence