Chlorotrimethylsilane → HCID 178504749, compound

Participants

Reaction Conditions

Reaction Steps

Zinc powder (2.81 g, 42.97 mmol) was suspended in THF (50 mL) under nitrogen and heated to 60° C. 1,2-dibromoethane (0.336 g, 1.79 mmol) was added and stirred for 15 min at 60° C. It was cooled to ambient temperature, TMSCl (0.156 g, 1.43 mmol) was added and stirred for 15 min at ambient temperature. 1-(Bromomethyl)-4-(methylsulfonyl)benzene (8.92 g, 35.81 mmol) dissolved in THF (50 mL) was added over 15 min and the resulting mixture was stirred at ambient temperature overnight. Stirring was stopped and the supernatant used in the next reaction.

Provenance & Evidence