Chlorotrimethylsilane → HCID 178505823, compound

Participants

Reaction Conditions

Reaction Steps

Zinc powder (2.62 g, 40.00 mmol) and lithium chloride (1.696 g, 40.00 mmol) were added to a dried flask and heated to 150° C. under vacuum for 30 min. The flask was allowed to reach room temperature. THF (20 mL) and 1,2-dibromoethane (0.115 mL, 1.33 mmol) were added. The mixture was heated until boiling occurred and the flask was then allowed to reach room temperature. Chlorotrimethylsilane (0.034 mL, 0.27 mmol) was added and the mixture was again heated until boiling occurred. The flask was cooled with an ice-bath and 5-(bromomethyl)-1,2,3-trifluorobenzene (6 g, 26.67 mmol) dissolved in THF (5 mL) was then added dropwise. The ice-bath was removed and the reaction stirred at room temperature for 20 h. Solids were allowed to settle and the supernatant used in the next transformation.

Provenance & Evidence