HCID 66732679, compound → HCID 66731834, compound

Participants

Reaction Steps

Methyl 2-(3,4,5-trifluorobenzyl)isonicotinate hydrochloride (4 g, 12.59 mmol) was dissolved in MeOH (45 mL) and platinum(IV) oxide (0.143 g, 0.63 mmol) added. The resulting mixture was hydrogenated in a Büchi hydrogenator at room temperature and 5 bar for 3 h. Additional platinum(IV) oxide (0.029 g, 0.13 mmol) was added and the hydrogenation continued for 20 min. The catalyst was filtered off and washed with MeOH. The filtrate was evaporated in vacuo to yield methyl 2-(3,4,5-trifluorobenzyl)piperidine-4-carboxylate hydrochloride (3.96 g, 97%) as a brown solid. MS m/z 288 (M+H)+

Provenance & Evidence