HCID 66731958, compound → HCID 66731768, compound

Participants

Reaction Steps

Methyl 2-(3,5-di-tert-butylbenzyl)isonicotinate (3.538 g, 10.42 mmol) was dissolved in acetic acid (30 mL) and platinum(IV) oxide (0.118 g, 0.52 mmol) added. The resulting mixture was hydrogenated in a Büchi hydrogenator at room temperature and 5 bar for 5 h 45 min. The catalyst was filtered off and washed with MeOH and the eluate evaporated. DCM and 10% K2CO3 were added and the phases separated. The organic layer was washed with brine, passed through a phase separator and evaporated to yield crude methyl 2-(3,5-di-tert-butylbenzyl)piperidine-4-carboxylate (3.80 g, 106%) as a beige oil. MS m/z 346 (M+H)+

Provenance & Evidence