Methyl chloroformate → HCID 66734972, compound

Participants

Reaction Steps

Methyl 2-(3,5-di-tert-butylbenzyl)piperidine-4-carboxylate (3.691 g, 10.68 mmol) was dissolved in DCM (80 mL) and DIPEA (2.233 mL, 12.82 mmol) added followed by methyl carbonochloridate (1.262 mL, 16.02 mmol). The solution was stirred at room temperature for 1.5 h. The reaction mixture was washed with 0.1 M HCl and satd NaHCO3. The organic phase was passed through a phase separator and evaporated to yield dimethyl 2-(3,5-di-tert-butylbenzyl)piperidine-1,4-dicarboxylate (3.91 g, 91%) as a yellow oil. MS m/z 404 (M+H)+

Provenance & Evidence