HCID 66734890, compound → HCID 46938035, compound

Participants

Reaction Steps

To (2S,4S)-methyl 2-benzyl-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate (0.99 g) was added HBr (33% in HOAc, 20 mL) and the solution was stirred for 8 h. The volatiles were concentrated and the residues purified by preparative HPLC on a XBridge C18 column (10 μm 250×50 ID mm) using a gradient of 0-40% acetonitrile in H2O/MeCN/NH3 95/5/0.2 buffer over 15 minutes with a flow of 100 mL/minutes. The title compound was isolated (0.62 g, 30%). 1H NMR (600 MHz, dmso) δ 1.47 (m, 1H), 1.67-1.83 (m, 3H), 2.51-2.67 (m, 3H), 2.74-2.89 (m, 2H), 3.04-3.15 (m, 1H), 5.67 (s, 1H), 7.21 (m, 5H); [α]20D +47.0 (MeOH/H2O 1:1, c=1); HRMS Calculated for [C15H19N2O2]+: 259.1447. Found: 259.1449.

Provenance & Evidence