HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 131730375, compound → HCID 66732616, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 131730375 | HCID 131730375 | — |
| Solvent | Isopropanol heptane | HCID 21225753 | — |
| Product | HCID 66732616 | HCID 66732616 | 44.3% |
Reaction Steps
Racemic trans-methyl 2-(2-methyl-2-phenylpropyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)-piperidine-1-carboxylate (0.82 g, 2.28 mmol) was subjected to chiral separation using Chiralcel IC, mobile phase heptane/IPA 80/20 at 40° C. which resulted in (2S,4S)-methyl 2-(2-methyl-2-phenylpropyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate (0.361 g, 1.01 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08415378B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-0433cc9c438c4c39a2666ce5b9be7d35 |
| Source note | uspto-grants-2013_04 |