Hydrogen Bromide → HCID 46938159, compound

Participants

Reaction Steps

HBr (33% in acetic acid) (5 mL) was added to (2R,4R)-methyl 2-(cyclohexylmethyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate (0.28 g, 0.87 mmol). The reaction was stirred vigorously overnight. The solvent was evaporated. Purification using PrepLC (pH=11, small column, no sandwitching, sample dissolved in methanol/water (50/50), gradient 15-55, 20 minutes). The title compound (57 mg, 25%) was obtained. 1H NMR (400 MHz, cd3od) δ 0.78-0.95 (m, 2H), 1.17 (dd, 3H), 1.28-1.48 (m, 4H), 1.63 (dd, 6H), 2.04 (d, 1H), 2.12 (d, 1H), 2.85 (t, 1H), 2.96 (dd, 1H), 3.13 (s, 1H), 3.31 (d, 1H), 5.40 (s, 1H).

Provenance & Evidence