Hydrogen Bromide → HCID 66732322, compound

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Reaction Steps

Trans-methyl 4-(3-oxo-2,3-dihydroisoxazol-5-yl)-2-(3-(trifluoromethyl)phenyl)piperidine-1-carboxylate (0.128 g, 0.35 mmol) was dissolved in hydrogen bromide (33% in acetic acid, 2.72 mL, 15.55 mmol) and the mixture was stirred at room temperature overnight. The solvent was evaporated and the residue purified by preparative HPLC (Instrument: FractionLynx II, Mobilphase: gradient 5-95% MeCN in 0.2% NH3, pH 10, Column: Xbridge Prep C18 5 μm OBD 19*150 mm) to yield 5-(trans-2-(3-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one (31 mg, 28%). 1H NMR (600 MHz, dmso) δ 1.77-1.86 (m, 2H), 1.86-1.93 (m, 1H), 2.01-2.08 (m, 1H), 2.71 (dt, 1H), 2.81-2.87 (m, 1H), 3.11-3.16 (m, 1H), 3.76-3.83 (m, 1H), 5.99 (s, 1H), 7.50-7.55 (m, 1H), 7.55-7.59 (m, 1H), 7.64-7.68 (m, 1H), 7.72 (s, 1H). HRMS Calculated for [C15H15F3N2O2+H]+: 313.1164. Found: 313.1153

Provenance & Evidence