Hydrogen Bromide → 5-((2R,4S)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one

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Reaction Steps

(2R,4S)-Methyl 4-(3-oxo-2,3-dihydroisoxazol-5-yl)-2-(4-(trifluoromethyl)phenyl)piperidine-1-carboxylate (580 mg, 1.57 mmol) was dissolved in hydrogen bromide (33% in acetic acid, 12 mL, 68.52 mmol) and the mixture stirred at room temperature for 17 h. The solvent was evaporated and the residue purified by preparative HPLC (Instrument: FractionLynx II, Mobilphase: gradient 5-95% MeCN in 0.2% NH3, pH 10, Column: Xbridge Prep C18 5 μm OBD 19*150 mm) to yield 5-((2R,4S)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one (341 mg, 70%). 1H NMR (600 MHz, cd3od) δ 1.68-1.79 (m, 2H), 2.10 (d, 1H), 2.21 (d, 1H), 2.98-3.10 (m, 2H), 3.35 (d, 1H), 3.99-4.07 (m, 1H), 5.64 (s, 1H), 7.60 (d, 2H), 7.66 (d, 2H). HRMS Calculated for [C15H15F3N2O2+H]+: 313.1164. Found: 313.1150

Provenance & Evidence