Hydrogen Bromide → HCID 66731817, compound

Participants

Reaction Steps

Trans-methyl 2-(4-(methylsulfonyl)phenyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate (301 mg, 0.79 mmol) was dissolved in hydrogen bromide (33% in acetic acid, 2 mL, 28.55 mmol) and stirred at room temperature for 20 h. The solvent was evaporated and the residue purified by preparative HPLC (Instrument: FractionLynx II, Mobilphase: gradient 5-95% MeCN in 0.2% NH3, pH 10, Column: Xbridge Prep C18 5 μm OBD 19*150 mm) to yield 5-(trans-2-(4-(methylsulfonyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one (119 mg, 47%), HRMS Calcd for [C15H18N2O4S+H]+: 323.1065. Found: 323.1054.

Provenance & Evidence