Hydrogen Bromide → 5-((2R,4S)-2-(2-fluoro-4-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one

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Reaction Steps

(2R,4S)-Methyl 2-(2-fluoro-4-(trifluoromethyl)phenyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate (0.96 g, 2.47 mmol) was dissolved in hydrogen bromide (33% in acetic acid, 19.48 mL, 111.25 mmol) and the mixture was stirred at room temperature overnight. The solvent was evaporated and the residue purified by preparative HPLC (Instrument: FractionLynx II, Mobilphase: gradient 5-95% MeCN in 0.2% NH3, pH 10, Column: Xbridge Prep C18 5 μm OBD 19*150 mm) to yield 5-((2R,4S)-2-(2-fluoro-4-(trifluoromethyl)phenyl)piperidin-4-yl)isoxazol-3(2H)-one (687 mg, 84%). 1H NMR (600 MHz, dmso) δ 1.36 (q, 1H), 1.48 (dq, 1H), 1.84-1.92 (m, 1H), 1.94-2.02 (m, 1H), 2.75 (dt, 1H), 2.92 (tt, 1H), 3.08-3.15 (m, 1H), 4.00 (d, 1H), 5.73 (s, 1H), 7.53-7.62 (m, 2H), 7.78 (t, 1H). HRMS Calculated for [C15H14F4N2O2+H]+: 331.1070. Found: 331.1086

Provenance & Evidence