HCID 131730436, compound → HCID 66734876, compound

Participants

Reaction Steps

Racemic trans-methyl 4-(3-oxo-2,3-dihydroisoxazol-5-yl)-2-phenylpiperidine-1-carboxylate (772 mg, 2.55 mmol) was subjected to chiral preparative HPLC (Column: Chiralpak AD (250×20), 5 μm particle size, mobile phase: Heptane/EtOH 75/25, flow rate 15 mL/min) to yield (2S,4S)-methyl 4-(3-oxo-2,3-dihydroisoxazol-5-yl)-2-phenylpiperidine-1-carboxylate (249 mg, 32%). Optical rotation [α]D20=+23.0 (acetonitrile, c=1), Chiral purity 99.7% ee.

Provenance & Evidence