Hydrogen Bromide → 5-((2R,4S)-2-(3-fluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one

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Reaction Steps

(2R,4S)-Methyl 2-(3-fluorobenzyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate (545 mg, 1.63 mmol) was dissolved in hydrogen bromide (33% in acetic acid, 10 mL, 57.10 mmol) and the mixture stirred at room temperature for 23 h. The solvent was evaporated and the residue purified by preparative HPLC (Instrument: FractionLynx I, Mobilphase: gradient 5-95% MeCN in 0.2% NH3, pH 10, Column: Xbridge Prep C18 5 μm OBD 19*150 mm) to yield 5-((2R,4S)-2-(3-fluorobenzyl)piperidin-4-yl)isoxazol-3(2H)-one (286 mg, 63.5%). 1H NMR (400 MHz, dmso) δ 1.09 (q, 1H), 1.36 (dq, 1H), 1.71-1.81 (m, 2H), 2.50-2.79 (m, 5H), 2.95-3.03 (m, 1H), 5.66 (s, 1H), 6.95-7.07 (m, 3H), 7.26-7.34 (m, 1H). HRMS Calculated for [C15H17FN2O2+H]+: 277.1352. Found: 277.1343

Provenance & Evidence