Hydrogen Bromide → 5-((2S,4R)-2-(3-fluoro-4-(trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one

Participants

Reaction Steps

(2S,4R)-Methyl 2-(3-fluoro-4-(trifluoromethyl)benzyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate (589 mg, 1.46 mmol) (from example 140, step 3) was dissolved in hydrogen bromide (33% in acetic acid, 10 mL, 57.10 mmol) and the mixture stirred at room temperature overnight. The solvent was evaporated and the residue purified by preparative HPLC (Instrument: FractionLynx III, Mobilphase: gradient 5-95% MeCN in 0.2% NH3, pH 10, Column: Xbridge Prep C18 5 μm OBD 19*150 mm) to yield 5-((2S,4R)-2-(3-fluoro-4-(trifluoromethyl)benzyl)piperidin-4-yl)isoxazol-3(2H)-one (329 mg, 65%). 1H NMR (600 MHz, cd3od) δ 1.66 (q, 1H), 1.81 (dq, 1H), 2.17-2.25 (m, 2H), 3.00-3.15 (m, 4H), 3.47-3.52 (m, 1H), 3.56-3.62 (m, 1H), 5.76 (s, 1H), 7.28 (dd, 2H), 7.67 (t, 1H). HRMS Calculated for [C16H16F4N2O2+H]+: 345.1226. Found: 345.1225

Provenance & Evidence