Acetic Acid → HCID 66732300, compound

Participants

Reaction Steps

(2R,4S)-Methyl 2-(3,5-di-tert-butylbenzyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate (550 mg, 1.28 mmol) was dissolved in hydrogen bromide (33% in acetic acid (10 mL, 57.10 mmol) and the mixture stirred at room temperature overnight. The solvent was evaporated and the residue purified by preparative HPLC (Instrument: FractionLynx III, Mobilphase: gradient 5-95% MeCN in 0.2% NH3, pH 10, Column: Xbridge Prep C18 5 μm OBD 19*150 mm) to yield 5-((2R,4S)-2-(3,5-di-tert-butylbenzyl)piperidin-4-yl)isoxazol-3(2H)-one (315 mg, 66%). 1H NMR (600 MHz, cd3od) δ 1.30 (s, 18H), 1.58-1.67 (m, 1H), 1.80 (dq, 1H), 2.17-2.27 (m, 2H), 2.85-3.14 (m, 4H), 3.41-3.51 (m, 2H), 5.73 (s, 1H), 7.07-7.13 (m, 2H), 7.36-7.40 (m, 1H). HRMS Calculated for [C23H34N2O2+H]+: 371.2698. Found: 371.2714

Provenance & Evidence