Hydrogen Bromide → HCID 66732084, compound

Participants

Reaction Steps

Trans-Methyl 2-(3,5-di-tert-butylbenzyl)-4-(3-oxo-2,3-dihydroisoxazol-5-yl)piperidine-1-carboxylate (155 mg, 0.36 mmol) was dissolved in hydrogen bromide (33% in acetic acid, 3 mL, 17.13 mmol) and the mixture stirred at room temperature overnight. The solvent was evaporated and the residue purified by preparative HPLC (Instrument: FractionLynx III, Mobilphase: gradient 5-95% MeCN in 0.2% NH3, pH 10, Column: Xbridge Prep C18 5 μm OBD 19*150 mm) to yield 5-(trans-2-(3,5-di-tert-butylbenzyl)piperidin-4-yl)isoxazol-3(2H)-one (69 mg, 51%). 1H NMR (600 MHz, DMSO) δ 1.26 (s, 18H), 1.45-1.53 (m, 1H), 1.69-1.87 (m, 3H), 2.58-2.72 (m, 3H), 2.83-2.93 (m, 2H), 3.09-3.16 (m, 1H), 5.64 (s, 1H), 6.99 (d, 2H), 7.18-7.23 (m, 1H). HRMS Calculated for [C23H34N2O2+H]+: 371.2698. Found: 371.2688

Provenance & Evidence