4-Bromo-2-fluorobenzene-1-sulfonyl chloride → 4-Bromo-2-fluoro-1-(phenylsulfonyl)benzene

HRID 1963663Notes

Reaction equation

HRID 1963663 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8](Cl)(=[O:10])=[O:9])=[C:4]([F:12])[CH:3]=1>[Fe](Cl)(Cl)Cl.C1C=CC=CC=1>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)(=[O:10])=[O:9])=[C:4]([F:12])[CH:3]=1

Participants

4

Reactant 1

HCID 27363104-Bromo-2-fluorobenzene-1-sulfonyl chloride

Product 1

HCID 673740874-Bromo-2-fluoro-1-(phenylsulfonyl)benzene

Reagents, catalysts & solvents 2

HCID 24380Iron chloride (FeCl3)CatalystHCID 241BenzeneSolvent

Procedure

4-Bromo-2-fluoro-benzenesulfonyl chloride (2 g), benzene (1.3 ml) and iron (III) chloride (35 mg) were heated in a sealed tube using a microwave at 200 Watts for 15 seconds. After cooling purification by flash column chromatography (eluent 20% EtOAc/Hexane) gave the subtitle compound as a solid, yield 1.8 g.

Workup

  1. customfor 15 seconds
  2. temperatureAfter cooling
  3. custompurification by flash column chromatography (eluent 20% EtOAc/Hexane)

Sources & evidence

ORD record
ord-4f57d37d7db74b53af693620025f26bf
Source dataset
uspto-grants-2013_04
Patent number
US08415394B2

Reaction notes

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