Acetic Acid → HCID 67239262, compound

HRID 1963680Notes

Reaction equation

HRID 1963680 reaction equation
C(O[C:9]1[CH:14]=[C:13]([S:15]([C:18]2[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=2)(=[O:17])=[O:16])[C:12]([F:26])=[CH:11][C:10]=1[C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([F:33])[CH:28]=1)C1C=CC=CC=1.[H][H].C(O)(=[O:38])C>[Pd]>[F:26][C:12]1[CH:11]=[C:10]([C:27]2[C:32]([OH:38])=[CH:31][CH:30]=[C:29]([F:33])[CH:28]=2)[CH:9]=[CH:14][C:13]=1[S:15]([C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[CH:20][CH:19]=1)(=[O:16])=[O:17]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 68089499HCID 68089499, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67239262HCID 67239262, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A suspension of the product of step (ii) (838 mg) in acetic acid (30 ml) and 10% Pd/C (200 mg) was stirred under 2 bar pressure of hydrogen for 30 min. The catalyst was removed by filtration and the filtrate was evaporated to give the subtitle compound, yield 630 mg.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-9d80e81b84a043689c79567b3e3b7abd
Source dataset
uspto-grants-2013_04
Patent number
US08415394B2

Reaction notes

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