5-Fluoro-2-methoxyphenylboronic acid → 2-Chloro-5'-fluoro-2'-methoxybiphenyl-4-yl phenyl sulfone

HRID 1963684Notes

Reaction equation

HRID 1963684 reaction equation
[C:1]1([S:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.BrC1C=CC(O)=CC=1[Cl:24].[F:25][C:26]1[CH:27]=[CH:28][C:29]([O:35][CH3:36])=[C:30](B(O)O)[CH:31]=1>>[C:1]1([S:7]([C:10]2[CH:15]=[CH:14][C:13]([C:28]3[CH:27]=[C:26]([F:25])[CH:31]=[CH:30][C:29]=3[O:35][CH3:36])=[C:12]([Cl:24])[CH:11]=2)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 27826735-Fluoro-2-methoxyphenylboronic acidHCID 68089427HCID 68089427, compound

Product 1

HCID 672389982-Chloro-5'-fluoro-2'-methoxybiphenyl-4-yl phenyl sulfone

Procedure

The subtitle compound was prepared by the method of example 2 step (ii) using the product of step (i) and 5-fluoro-2-methoxybenzene boronic acid.

Sources & evidence

ORD record
ord-918ae60fba3e4324a44ca01f3ceb0c56
Source dataset
uspto-grants-2013_04
Patent number
US08415394B2

Reaction notes

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