(2-Methoxy-5-methylphenyl)boronic acid → 3'-Fluoro-2-methoxy-5-methyl-4'-(phenylsulfonyl)biphenyl

HRID 1963696Notes

Reaction equation

HRID 1963696 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[C:4]([F:17])[CH:3]=1.[CH3:18][O:19][C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][C:21]=1B(O)O>>[F:17][C:4]1[CH:3]=[C:2]([C:21]2[CH:22]=[C:23]([CH3:26])[CH:24]=[CH:25][C:20]=2[O:19][CH3:18])[CH:7]=[CH:6][C:5]=1[S:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 2773485(2-Methoxy-5-methylphenyl)boronic acidHCID 673740874-Bromo-2-fluoro-1-(phenylsulfonyl)benzene

Product 1

HCID 684359733'-Fluoro-2-methoxy-5-methyl-4'-(phenylsulfonyl)biphenyl

Procedure

The subtitle compound was prepared by the method of example 2 step (ii) using the product of example 2 step (i) and (2-methoxy-5-methylphenyl)boronic acid.

Sources & evidence

ORD record
ord-7e97912c263a4bbfb9b4d374452a0d16
Source dataset
uspto-grants-2013_04
Patent number
US08415394B2

Reaction notes

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