5-Chloro-2-methoxyphenylboronic acid → 5'-Chloro-3,5-difluoro-2'-methoxybiphenyl-4-yl phenyl sulfone

HRID 1963697Notes

Reaction equation

HRID 1963697 reaction equation
[C:1]1([S:7]([C:10]2[C:15]([F:16])=[CH:14][C:13](Br)=[CH:12][C:11]=2[F:18])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([O:29][CH3:30])=[C:24](B(O)O)[CH:25]=1>>[C:1]1([S:7]([C:10]2[C:15]([F:16])=[CH:14][C:13]([C:22]3[CH:21]=[C:20]([Cl:19])[CH:25]=[CH:24][C:23]=3[O:29][CH3:30])=[CH:12][C:11]=2[F:18])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 27357515-Chloro-2-methoxyphenylboronic acidHCID 684362694-Bromo-2,6-difluorophenyl phenyl sulfone

Product 1

HCID 672400705'-Chloro-3,5-difluoro-2'-methoxybiphenyl-4-yl phenyl sulfone

Procedure

The subtitle compound was prepared by the method of example 2 step (ii) using the product of step (i) and 5-chloro-2-methoxybenzene boronic acid which was used directly in step (iv) without further characterisation.

Sources & evidence

ORD record
ord-e5e1ff3ec91e4a79b1f80c249e7ff5fd
Source dataset
uspto-grants-2013_04
Patent number
US08415394B2

Reaction notes

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