HRID1963706

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7918

Acetic anhydride

C4H6O3

结构：Cn1c(Nc2cc(C(F)(F)F)ccc2F)nc2cc(Oc3ccnc(NC(=O)C4CCNCC4)c3)ccc21

HCID59790243

未命名化合物

PRODUCTS

生成物

结构：CC(=O)N1CCC(C(=O)Nc2cc(Oc3ccc4c(c3)nc(Nc3cc(C(F)(F)F)ccc3F)n4C)ccn2)CC1

HCID59789963

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

To N-{4-[(2-{[2-fluoro-5-(trifluoromethyl)phenyl]amino}-1-methyl-1H-benzimidazol-5-yl)oxy]pyridin-2-yl}piperidine-4-carboxamide (1 eq) in dioxane and N,N-disopropylethylamine (2 eq) was added acetic anhydride (1 eq) and the resulting mixture was stirred for 1 h. 1-acetyl-N-{4-[(2-{[2-fluoro-5-(trifluoromethyl)phenyl]amino}-1-methyl-1H-benzimidazol-5-yl)oxy]pyridin-2-yl}piperidine-4-carboxamide thus formed was purified by preparative chromatography. MS: MH+=571.5.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9b5d03039b6e47e38d1d1a3c328483f4
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08415382B2
来源说明: uspto-grants-2013_04

反应 SMILES

[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[NH:12][C:13]1[N:17]([CH3:18])[C:16]2[CH:19]=[CH:20][C:21]([O:23][C:24]3[CH:29]=[CH:28][N:27]=[C:26]([NH:30][C:31]([CH:33]4[CH2:38][CH2:37][NH:36][CH2:35][CH2:34]4)=[O:32])[CH:25]=3)=[CH:22][C:15]=2[N:14]=1.[C:39](OC(=O)C)(=[O:41])[CH3:40]>O1CCOCC1>[C:39]([N:36]1[CH2:37][CH2:38][CH:33]([C:31]([NH:30][C:26]2[CH:25]=[C:24]([O:23][C:21]3[CH:20]=[CH:19][C:16]4[N:17]([CH3:18])[C:13]([NH:12][C:3]5[CH:4]=[C:5]([C:8]([F:9])([F:10])[F:11])[CH:6]=[CH:7][C:2]=5[F:1])=[N:14][C:15]=4[CH:22]=3)[CH:29]=[CH:28][N:27]=2)=[O:32])[CH2:34][CH2:35]1)(=[O:41])[CH3:40]