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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1963725Generated: October 31, 2026

Trifluoroacetic acid → 4-(2-Methoxy-4-(methylamino)-5-nitrophenoxy)pyridine-2-carboxylic acid

https://huagongshe.com/reaction/1963725

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
ReactantHCID 69003260HCID 69003260—
Product4-(2-Methoxy-4-(methylamino)-5-nitrophenoxy)pyridine-2-carboxylic acidHCID 69001904—

Reaction Steps

Trifluoroacetic acid was added neat to tert-butyl 4-(2-methoxy-4-(methylamino)-5-nitrophenoxy)pyridine-2-carboxylate and stirred at room temperature for 5 hours. TFA was evaporated, solid product azeotroped with toluene then placed under vacuum for 24 hours to yield 4-(2-methoxy-4-(methylamino)-5-nitrophenoxy)pyridine-2-carboxylic acid. HPLC=3.07 min; MS: MH+=321

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08415382B2
Source datasetuspto-grants-2013_04
ORD IDord-323360743b0248df8df70624464a6284
Source noteuspto-grants-2013_04