2-Methyl-4-nitrophenol → HCID 68752044, compound

Participants

Reaction Steps

To an acetonitrile (50 mL) solution of 2-methyl-4-nitrophenol (3.05 g; 19.9 mmol) and potassium carbonate (4.27 g; 30.9 mmol), 4-bromo-1-butene (4.02 g; 29.8 mmol) was added, and the mixture was refluxed and then reacted for 12 hours. After completion of the reaction, the solution was filtrated by Celite, and then filtrate was concentrated under a reduced pressure. The residue was purified by flash column chromatography using methylene chloride, and then the effluent was concentrated to obtain 4-(3-butenyloxy)-2-methylnitrobenzene (1c) (2.61 g, 63% of yield, a light yellow oil) represented by the following formula.

Provenance & Evidence