2-Fluoro-4-nitrophenol → HCID 68748084, compound

Participants

Reaction Steps

To an acetonitrile (40 mL) solution of 2-fluoro-4-nitrophenol (2.36 g; 15.1 mmol) and potassium carbonate (2.77 g; 20.1 mmol), 4-bromo-1-butene (2.81 g; 20.4 mmol) was added, and the mixture was refluxed and then reacted for 16 hours. After completion of the reaction, the solution was filtrated by Celite, and then the filtrate was concentrated under a reduced pressure. The residue was purified by flash column chromatography using methylene chloride, and then the effluent was concentrated to obtain 4-(3-butenyloxy)-3-fluoronitrobenzene (1d) (2.57 g, 81% of yield, a light yellow oil) represented by the following formula.

Provenance & Evidence