Trifluoroacetic acid → HCID 44608430, compound

Participants

Reaction Conditions

Reaction Steps

(Some starting materials may be obtained from Asta Tech, Inc., Princeton, N.J.) To a solution of tert-butyl 3-((7-(6-chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)quinoxalin-2-ylamino)methyl)piperidine-1-carboxylate (5 mg, 8 μmol) in DCM (1 mL) was added TFA (1 mL) and the reaction was stirred at 23° C. for 15 min. The reaction was then concentrated in vacuo and coevaporated with DCM (3×; 1 ml) to give the desired product as a yellow film. MS (ESI pos. ion) m/z calc'd for C25H24ClFN6O2S: 526.1; found 527.0. 1H NMR (300 MHz, CDCl3) δ ppm 1.23-1.38 (m, 2 H) 1.78 (m, 1 H) 1.89 (m, 2 H) 2.22 (br. s., 1 H) 2.66 (t, J=11.84 Hz, 1 H) 2.79 (d, J=3.07 Hz, 1 H) 3.36-3.52 (m, 3 H) 7.05-7.12 (m, 2 H) 7.48 (dd, J=8.48, 2.05 Hz, 1 H) 7.71-7.88 (m, 4 H) 8.19-8.23 (m, 2 H) 8.38-8.41 (m, 1 H)

Provenance & Evidence