Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- | HCID 18462 | — |
| Reactant | 1,6-Dioxaspiro[2.5]octane | HCID 160439 | — |
| Product | (4-Methoxyoxan-4-yl)methanol | HCID 66937097 | — |
Reaction Steps
To a solution of 1,6-dioxaspiro[2.5]octane (600 mg, 5.26 mmol) in methanol (10 ml) at 0° C. (ice-water) under nitrogen was added camphorsulfonic acid (50 mg, 0.21 mmol) and the resulting mixture was stirred at about 0° C. for 2 hours. The mixture was concentrated in vacuo and the crude residue was used in the next step without purification. The desired product was obtained as a light yellow oil (707 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08415381B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-41a722880ba54f77a4c00e2c32d8f7c2 |
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| Source note | uspto-grants-2013_04 |
|---|
